Conradi-Hünermann-Happle syndrome: Clinical and trichoscopic findings.

Conradi-Hünermann-Happle syndrome (CHHS) is a rare genodermatosis resulting from mutations in the EBP (emopamil binding protein) gene. Dermatologic manifestations may include cicatricial alopecia, ichthyosis, follicular atrophoderma, pigmentary abnormalities, and nail dystrophy. In addition to genetic testing and clinical findings, trichoscopic findings may aid in the diagnosis. In this case report, we discuss the trichoscopic findings in a 3-year-old girl with CHHS and how these findings help us understand the pathophysiology of this disease.

Abnormal Nailfold Capillaroscopy in a Patient With Multisystem Inflammatory Syndrome in Children.

Multisystem inflammatory syndrome in children (MIS-C) is an emerging entity during the coronavirus disease 2019 pandemic. Medium- and large-vessel changes are present in MIS-C; however, microcirculatory impairment has not been documented. We report a case of MIS-C in a toddler that presented with persistent fever, gastrointestinal symptoms and rash. Nailfold videocapillaroscopy was abnormal, suggesting microcirculatory disease in the setting of MIS-C.

Úlcera vulvar en una paciente de 15 años: ¿se puede reconocer la alergia a fármacos? / Vulvar ulcer in a 15-year-old girl: can we recognize adverse drug reactions?

Introducción. Los pediatras consideran la úlcera vulvar como una patología poco común. Sin embargo, los médicos que se especializan en la atención de adolescentes y niñas con patología vulvar consideran las úlceras vulvares como un motivo de consulta frecuente. Caso clínico. Se trató de un paciente femenino de 15 años con cuadro de fiebre y dolor faríngeo diagnosticado como faringitis bacteriana. Recibió tratamiento con trimetoprima-sulfametoxazol. Dos días después cursó con aparición de placas hiperpigmentadas de centro ampolloso, que evolucionaron a una úlcera de aproximadamente 4 cm de diámetro. Inicialmente se consideró un origen infeccioso de la lesión y se manejó con fluconazol tópico; posteriormente, amoxicilina clavulanato. No presentó mejoría y, tras la valoración por el dermatólogo, se diagnosticó eritema pigmentado fijo con base en la morfología de lesión inicial. Recibió tratamiento con betametasona y loratadina oral, así como hidrocortisona tópica al 1%. Evolucionó con resolución de las lesiones. Conclusiones. En la práctica del pediatra es trascendental conservar en mente no solo la patología de origen infeccioso y venéreo en las pacientes adolescentes con úlcera vulvar, sino también las reacciones de alergia a fármacos.

Background. Pediatricians consider vulvar ulcer as an uncommon pathology. However, clinicians specialized in the care of young girls and teenagers with vulvar pathology actually consider vulvar ulcer not to be an infrequent primary complaint. Case report. We report the case of a 15-year-old girl who presented fever and sore throat for which she was treated with trimethoprim-sulfamethoxazol. Two days after taking the drug she presented hyperpigmented patches with a bullous center that developed into an ulcer of ~4 cm in diameter. First considered infectious in origin, she received treatment with topical fluconazol and afterwards with amoxicillin clavulanate without any improvement. She was then assessed by a dermatologist, and the diagnosis of fixed drug eruption was established on the basis of the initial morphology of the lesion. She was treated with betamethasone and loratadine as well as topical 1% hydrocortisone. The lesions evolved to complete resolution. Conclusions. In pediatric practice, it is important for the pediatrician to consider not only infectious and venereal causes in teenage girls with vulvar ulcer, but also allergic drug reactions.